Intersectin

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*'''ITSN-1 short form''' is 140kD and expressed in all tissues
*'''ITSN-1 short form''' is 140kD and expressed in all tissues
*'''ITSN-1 long form''' is 200kD and expressed in neutrons, eye, heart, blood cells and kidney<ref>PMID:32161523</ref>.
*'''ITSN-1 long form''' is 200kD and expressed in neutrons, eye, heart, blood cells and kidney<ref>PMID:32161523</ref>.
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*'''ITSN-2 short form''' contains 2 EH domains, a coiled-coil domain and 5 SH3 domains
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*'''ITSN-2 long form'''contains an extra carboxylate domain<ref>PMID:10922467</ref>.
== Relevance ==
== Relevance ==

Revision as of 11:49, 7 July 2024

Human intersectin 1 short isoform 4th SH3 domain (green, yellow, cyan, purple) complex with FCSHD2 SH3 2nd domain (deepskyblue, pink, light pink, orange) (PDB code 6gbu)

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3D structures of intersectin

Updated on 07-July-2024

References

  1. ↑ . Correction for Gerth et al., Intersectin associates with synapsin and regulates its nanoscale localization and function. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E11060. doi:, 10.1073/pnas.1720226115. Epub 2017 Dec 11. PMID:29229830 doi:http://dx.doi.org/10.1073/pnas.1720226115
  2. ↑ Ma N, Niu RF, Ma YJ. Intersectin 1: a molecular linker in the central nervous system. Neurosci Bull. 2008 Dec;24(6):401-5. doi: 10.1007/s12264-008-0715-0. PMID:19037327 doi:http://dx.doi.org/10.1007/s12264-008-0715-0
  3. ↑ Pucharcos C, Estivill X, de la Luna S. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett. 2000 Jul 28;478(1-2):43-51. doi: 10.1016/s0014-5793(00)01793-2. PMID:10922467 doi:http://dx.doi.org/10.1016/s0014-5793(00)01793-2
  4. ↑ Malakooti N, Pritchard MA, Chen F, Yu Y, Sgambelloni C, Adlard PA, Finkelstein DI. The Long Isoform of Intersectin-1 Has a Role in Learning and Memory. Front Behav Neurosci. 2020 Feb 25;14:24. PMID:32161523 doi:10.3389/fnbeh.2020.00024
  5. ↑ Pucharcos C, Estivill X, de la Luna S. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett. 2000 Jul 28;478(1-2):43-51. doi: 10.1016/s0014-5793(00)01793-2. PMID:10922467 doi:http://dx.doi.org/10.1016/s0014-5793(00)01793-2
  6. ↑ Russo A, O'Bryan JP. Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 2012 Nov 15;31(46):4828-34. doi: 10.1038/onc.2011.643. Epub 2012 Jan, 23. PMID:22266851 doi:http://dx.doi.org/10.1038/onc.2011.643
  7. ↑ Li J, Bu X, Chen X, Xiong P, Chen Z, Yu L. Predictive value of long non-coding RNA intersectin 1-2 for occurrence and in-hospital mortality of severe acute pancreatitis. J Clin Lab Anal. 2019 Dec 27:e23170. doi: 10.1002/jcla.23170. PMID:31880027 doi:http://dx.doi.org/10.1002/jcla.23170
  8. ↑ Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26;22(15):767-72. doi: 10.1097/WNR.0b013e32834ae348. PMID:21876463 doi:http://dx.doi.org/10.1097/WNR.0b013e32834ae348
  9. ↑ Almeida-Souza L, Frank RAW, Garcia-Nafria J, Colussi A, Gunawardana N, Johnson CM, Yu M, Howard G, Andrews B, Vallis Y, McMahon HT. A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Cell. 2018 Jun 4. pii: S0092-8674(18)30597-X. doi: 10.1016/j.cell.2018.05.020. PMID:29887380 doi:http://dx.doi.org/10.1016/j.cell.2018.05.020

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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