8gix

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Current revision (08:40, 14 July 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8gix is ON HOLD
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==Chaetomium thermophilum Hir3==
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<StructureSection load='8gix' size='340' side='right'caption='[[8gix]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GIX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gix OCA], [https://pdbe.org/8gix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gix RCSB], [https://www.ebi.ac.uk/pdbsum/8gix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gix ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G0S723_CHATD G0S723_CHATD] Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.[ARBA:ARBA00002687]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1a/Asf1 co-chaperone cooperate to deposit histone (H3/H4)(2) tetramers on DNA for replication-independent chromatin assembly. The molecular architecture of the HIRA/Hir complex and its mode of histone deposition have remained unknown. Here, we report the cryo-EM structure of the S. cerevisiae Hir complex with Asf1/H3/H4 at 2.9-6.8 A resolution. We find that the Hir complex forms an arc-shaped dimer with a Hir1/Hir2/Hir3/Hpc2 stoichiometry of 2/4/2/4. The core of the complex containing two Hir1/Hir2/Hir2 trimers and N-terminal segments of Hir3 forms a central cavity containing two copies of Hpc2, with one engaged by Asf1/H3/H4, in a suitable position to accommodate a histone (H3/H4)(2) tetramer, while the C-terminal segments of Hir3 harbor nucleic acid binding activity to wrap DNA around the Hpc2-assisted histone tetramer. The structure suggests a model for how the Hir/Asf1 complex promotes the formation of histone tetramers for their subsequent deposition onto DNA.
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Authors:
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Structure of the Hir histone chaperone complex.,Kim HJ, Szurgot MR, van Eeuwen T, Ricketts MD, Basnet P, Zhang AL, Vogt A, Sharmin S, Kaplan CD, Garcia BA, Marmorstein R, Murakami K Mol Cell. 2024 Jun 20:S1097-2765(24)00478-7. doi: 10.1016/j.molcel.2024.05.031. PMID:38925115<ref>PMID:38925115</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 8gix" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
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[[Category: Large Structures]]
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[[Category: Kim HJ]]
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[[Category: Marmorstein R]]
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[[Category: Szurgot MR]]
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[[Category: Van Eeuwen T]]

Current revision

Chaetomium thermophilum Hir3

PDB ID 8gix

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