1suv

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[[Image:1suv.jpg|left|200px]]
[[Image:1suv.jpg|left|200px]]
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{{Structure
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|PDB= 1suv |SIZE=350|CAPTION= <scene name='initialview01'>1suv</scene>
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The line below this paragraph, containing "STRUCTURE_1suv", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= TFRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), TF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1suv| PDB=1suv | SCENE= }}
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|RELATEDENTRY=[[1jnf|1JNF]], [[1cx8|1CX8]], [[1a8e|1A8E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1suv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1suv OCA], [http://www.ebi.ac.uk/pdbsum/1suv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1suv RCSB]</span>
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'''Structure of Human Transferrin Receptor-Transferrin Complex'''
'''Structure of Human Transferrin Receptor-Transferrin Complex'''
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[[Category: Walz, T.]]
[[Category: Walz, T.]]
[[Category: Zak, O.]]
[[Category: Zak, O.]]
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[[Category: protein complex]]
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[[Category: Protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:09:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:16 2008''
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Revision as of 06:09, 3 May 2008

Image:1suv.jpg

Template:STRUCTURE 1suv

Structure of Human Transferrin Receptor-Transferrin Complex


Contents

Overview

Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. Using cryo-electron microscopy, we have produced a density map of the TfR-Tf complex at subnanometer resolution. An atomic model, obtained by fitting crystal structures of diferric Tf and the receptor ectodomain into the map, shows that the Tf N-lobe is sandwiched between the membrane and the TfR ectodomain and that the C-lobe abuts the receptor helical domain. When Tf binds receptor, its N-lobe moves by about 9 A with respect to its C-lobe. The structure of TfR-Tf complex helps account for known differences in the iron-release properties of free and receptor bound Tf.

Disease

Known disease associated with this structure: Atransferrinemia OMIM:[190000], Iron deficiency anemia, susceptibility to OMIM:[190000]

About this Structure

1SUV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human transferrin receptor-transferrin complex., Cheng Y, Zak O, Aisen P, Harrison SC, Walz T, Cell. 2004 Feb 20;116(4):565-76. PMID:14980223 Page seeded by OCA on Sat May 3 09:09:40 2008

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