7o6q
From Proteopedia
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<StructureSection load='7o6q' size='340' side='right'caption='[[7o6q]], [[Resolution|resolution]] 1.88Å' scene=''> | <StructureSection load='7o6q' size='340' side='right'caption='[[7o6q]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O6Q FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6q OCA], [https://pdbe.org/7o6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6q RCSB], [https://www.ebi.ac.uk/pdbsum/7o6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6q ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.88Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6q OCA], [https://pdbe.org/7o6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6q RCSB], [https://www.ebi.ac.uk/pdbsum/7o6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Enzyme catalysis has emerged as a key technology for developing efficient, sustainable processes in the chemical, biotechnological and pharmaceutical industries. Plants provide large and diverse pools of biosynthetic enzymes that facilitate complex reactions, such as the formation of intricate terpene carbon skeletons, with exquisite specificity. High-resolution structural analysis of these enzymes is crucial in order to understand their mechanisms and modulate their properties by targeted engineering. Although cryo-electron microscopy (cryoEM) has revolutionized structural biology, its applicability to high-resolution structural analysis of comparatively small enzymes has so far been largely unexplored. Here, it is shown that cryoEM can reveal the structures of plant borneol dehydrogenases of approximately 120 kDa at or below 2 A resolution, paving the way for the rapid development of new biocatalysts that can provide access to bioactive terpenes and terpenoids. | ||
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| - | CryoEM analysis of small plant biocatalysts at sub-2 A resolution.,Dimos N, Helmer CPO, Chanique AM, Wahl MC, Kourist R, Hilal T, Loll B Acta Crystallogr D Struct Biol. 2022 Jan 1;78(Pt 1):113-123. doi:, 10.1107/S205979832101216X. Epub 2022 Jan 1. PMID:34981767<ref>PMID:34981767</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 7o6q" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dimos | + | [[Category: Dimos N]] |
| - | [[Category: Helmer | + | [[Category: Helmer CPO]] |
| - | [[Category: Hilal | + | [[Category: Hilal T]] |
| - | [[Category: Loll | + | [[Category: Loll B]] |
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Current revision
Structure of the borneol dehydrogenase 1 of salvia rosmarinus
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Categories: Large Structures | Dimos N | Helmer CPO | Hilal T | Loll B
