Neurotrophin
From Proteopedia
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'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor (BDNF) which is a member of the tumor necrosis factor receptor superfamily. | '''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor (BDNF) which is a member of the tumor necrosis factor receptor superfamily. | ||
*'''Neurotrophin 3''' is released through the regulated secretory pathway and influences the development of the enteric nervous system<ref>PMID:14699968</ref>. | *'''Neurotrophin 3''' is released through the regulated secretory pathway and influences the development of the enteric nervous system<ref>PMID:14699968</ref>. | ||
| - | *'''Neurotrophin 4''' is released through the constitutive secretory pathway <ref>PMID: | + | *'''Neurotrophin 4''' is released through the constitutive secretory pathway <ref>PMID:12970359</ref>. |
== Relevance == | == Relevance == | ||
Current revision
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3D structures of neurotrophin
Updated on 17-July-2024
1b8k, 1nt3 – hNT3 – human
3buk – hNT3 + P75NTR
1bnd – hNT3 139-257 + BDNF
1b98 – hNT4 81-210
1b8m, 1hcf – hNT4 81-210 + BDNF
References
- ↑ Facci L, Skaper SD. Culture of rat cerebellar granule neurons and application to identify neuroprotective agents. Methods Mol Biol. 2012;846:23-37. doi: 10.1007/978-1-61779-536-7_3. PMID:22367798 doi:http://dx.doi.org/10.1007/978-1-61779-536-7_3
- ↑ Chalazonitis A. Neurotrophin-3 in the development of the enteric nervous system. Prog Brain Res. 2004;146:243-63. PMID:14699968 doi:10.1016/S0079-6123(03)46016-0
- ↑ Hibbert AP, Morris SJ, Seidah NG, Murphy RA. Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway. J Biol Chem. 2003 Nov 28;278(48):48129-36. PMID:12970359 doi:10.1074/jbc.M300961200
- ↑ Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163
- ↑ Gong Y, Cao P, Yu HJ, Jiang T. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 2008 Aug 7;454(7205):789-93. Epub 2008 Jul 2. PMID:18596692 doi:10.1038/nature07089
