Nitroreductase
From Proteopedia
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'''Nitroreductase''' or '''oxygen-insensitive NAD(P)H nitroreductase''' (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO<sub>2</sub> group. The NO<sub>2</sub> group is reduced to hydroxylamine<ref>PMID:11491290</ref>. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. | '''Nitroreductase''' or '''oxygen-insensitive NAD(P)H nitroreductase''' (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO<sub>2</sub> group. The NO<sub>2</sub> group is reduced to hydroxylamine<ref>PMID:11491290</ref>. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. | ||
*'''Copper-induced nitroreductase''' protects ''Lactococcus lactis'' against oxidative stress exerted by nitroaromatic compounds and copper<ref>PMID:20562311</ref>. | *'''Copper-induced nitroreductase''' protects ''Lactococcus lactis'' against oxidative stress exerted by nitroaromatic compounds and copper<ref>PMID:20562311</ref>. | ||
| + | *'''Nitrobenzoate nitroreductase''' metabolises 2-nitrobenzoate to form the antioxidant 3-hydroxyanthranilate in ''Pseudomonas fluorescens''<ref>PMID:17277060</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 08:56, 17 July 2024
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References
- ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
- ↑ Mermod M, Mourlane F, Waltersperger S, Oberholzer AE, Baumann U, Solioz M. Structure and function of CinD (YtjD) of Lactococcus lactis, a copper-induced nitroreductase involved in defense against oxidative stress. J Bacteriol. 2010 Aug;192(16):4172-80. Epub 2010 Jun 18. PMID:20562311 doi:10.1128/JB.00372-10
- ↑ Iwaki H, Muraki T, Ishihara S, Hasegawa Y, Rankin KN, Sulea T, Boyd J, Lau PC. Characterization of a pseudomonad 2-nitrobenzoate nitroreductase and its catabolic pathway-associated 2-hydroxylaminobenzoate mutase and a chemoreceptor involved in 2-nitrobenzoate chemotaxis. J Bacteriol. 2007 May;189(9):3502-14. PMID:17277060 doi:10.1128/JB.01098-06
- ↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650
