1svf
From Proteopedia
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'''PARAMYXOVIRUS SV5 FUSION PROTEIN CORE''' | '''PARAMYXOVIRUS SV5 FUSION PROTEIN CORE''' | ||
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[[Category: Jardetzky, T S.]] | [[Category: Jardetzky, T S.]] | ||
[[Category: Lamb, R A.]] | [[Category: Lamb, R A.]] | ||
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| - | [[Category: | + | [[Category: Fusion]] |
| - | [[Category: | + | [[Category: Paramyxovirus]] |
| - | [[Category: | + | [[Category: Sv5]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:10:45 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:10, 3 May 2008
PARAMYXOVIRUS SV5 FUSION PROTEIN CORE
Overview
Paramyxoviruses are responsible for significant human mortality and disease worldwide, but the molecular mechanisms underlying their entry into host cells remain poorly understood. We have solved the crystal structure of a fragment of the simian parainfluenza virus 5 fusion protein (SV5 F), revealing a 96 A long coiled coil surrounded by three antiparallel helices. This structure places the fusion and transmembrane anchor of SV5 F in close proximity with a large intervening domain at the opposite end of the coiled coil. Six amino acids, potentially part of the fusion peptide, form a segment of the central coiled coil, suggesting that this structure extends into the membrane. Deletion mutants of SV5 F indicate that putative flexible tethers between the coiled coil and the viral membrane are dispensable for fusion. The lack of flexible tethers may couple a final conformational change in the F protein directly to the fusion of two bilayers.
About this Structure
1SVF is a Protein complex structure of sequences from Simian virus 5. Full crystallographic information is available from OCA.
Reference
Structural basis for paramyxovirus-mediated membrane fusion., Baker KA, Dutch RE, Lamb RA, Jardetzky TS, Mol Cell. 1999 Mar;3(3):309-19. PMID:10198633 Page seeded by OCA on Sat May 3 09:10:45 2008
