1svr

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[[Image:1svr.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1svr", creates the "Structure Box" on the page.
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{{STRUCTURE_1svr| PDB=1svr | SCENE= }}
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|RELATEDENTRY=[[1svq|1SVQ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1svr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svr OCA], [http://www.ebi.ac.uk/pdbsum/1svr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1svr RCSB]</span>
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'''STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION'''
'''STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION'''
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[[Category: Holak, T A.]]
[[Category: Holak, T A.]]
[[Category: Schnuchel, A.]]
[[Category: Schnuchel, A.]]
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[[Category: actin-binding]]
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[[Category: Actin-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:11:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:36 2008''
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Revision as of 06:11, 3 May 2008

Image:1svr.gif

Template:STRUCTURE 1svr

STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION


Overview

The three-dimensional structure of domain 2 of severin in aqueous solution was determined by nuclear magnetic resonance spectroscopy. Severin is a Ca(2+)-activated actin-binding protein that servers F-actin, nucleates actin assembly, and caps the fast-growing ends of actin filaments. The 114-residue domain consists of a central five-stranded beta-sheet, sandwiched between a parallel four-turn alpha-helix and, on the other face, a roughly perpendicular two-turn alpha-helix. There are two distinct binding sites for Ca2+ located near the N and C termini of the long helix. Conserved residues of the gelsolin-severin family contribute to the apolar core of domain 2 of severin, so that the overall fold of the protein is similar to those of segment 1 of gelsolin and profilins. Together with biochemical experiments, this structure helps to explain how severin interacts with actin.

About this Structure

1SVR is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Structure of severin domain 2 in solution., Schnuchel A, Wiltscheck R, Eichinger L, Schleicher M, Holak TA, J Mol Biol. 1995 Mar 17;247(1):21-7. PMID:7897658 Page seeded by OCA on Sat May 3 09:11:37 2008

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