7p0z

<table><tr><td colspan='2'>[[7p0z]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P0Z FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">espB, MMAR_5457 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>

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== Publication Abstract from PubMed ==

ESX-1 is a major virulence factor of Mycobacterium tuberculosis, a secretion machinery directly involved in the survival of the microorganism from the immune system defence. It disrupts the phagosome membrane of the host cell through a contact-dependent mechanism. Recently, the structure of the inner-membrane core complex of the homologous ESX-3 and ESX-5 was resolved; however, the elements involved in the secretion through the outer membrane or those acting on the host cell membrane are unknown. Protein substrates might form this missing element. Here, we describe the oligomerisation process of the ESX-1 substrate EspB, which occurs upon cleavage of its C-terminal region and is favoured by an acidic environment. Cryo-electron microscopy data shows that quaternary structure of EspB is conserved across slow growing species, but not in the fast growing M. smegmatis. EspB assembles into a channel with dimensions and characteristics suitable for the transit of ESX-1 substrates, as shown by the presence of another EspB trapped within. Our results provide insight into the structure and assembly of EspB, and suggests a possible function as a structural element of ESX-1.

Priming mycobacterial ESX-secreted protein B to form a channel-like structure.,Gijsbers A, Vinciauskaite V, Siroy A, Gao Y, Tria G, Mathew A, Sanchez-Puig N, Lopez-Iglesias C, Peters PJ, Ravelli RBG Curr Res Struct Biol. 2021 Jun 30;3:153-164. doi: 10.1016/j.crstbi.2021.06.001., eCollection 2021. PMID:34337436<ref>PMID:34337436</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 7p0z" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Gijsbers, A]]

[[Category: Lopez-Iglesias, C]]

[[Category: Mathew, A]]

[[Category: Peters, P J]]

[[Category: Ravelli, R B.G]]

[[Category: Sanchez-Puig, N]]

[[Category: Siroy, A]]

[[Category: Tria, G]]

[[Category: Vinciauskaite, V]]

[[Category: Ye, G]]

[[Category: Zhang, Y]]

[[Category: Protein transport]]