7qg9
From Proteopedia
(Difference between revisions)
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<StructureSection load='7qg9' size='340' side='right'caption='[[7qg9]], [[Resolution|resolution]] 3.45Å' scene=''> | <StructureSection load='7qg9' size='340' side='right'caption='[[7qg9]], [[Resolution|resolution]] 3.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7qg9]] is a 27 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[7qg9]] is a 27 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T5 Escherichia phage T5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QG9 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.45Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.45Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qg9 OCA], [https://pdbe.org/7qg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qg9 RCSB], [https://www.ebi.ac.uk/pdbsum/7qg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qg9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qg9 OCA], [https://pdbe.org/7qg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qg9 RCSB], [https://www.ebi.ac.uk/pdbsum/7qg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qg9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/COLLR_BPT5 COLLR_BPT5] Forms the collar, into which the side tail fiber protein pb1 is anchored.<ref>PMID:36961893</ref> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Most bacteriophages present a tail allowing host recognition, cell wall perforation, and viral DNA channeling from the capsid to the infected bacterium cytoplasm. The majority of tailed phages bear a long flexible tail (Siphoviridae) at the tip of which receptor binding proteins (RBPs) specifically interact with their host, triggering infection. In siphophage T5, the unique RBP is located at the extremity of a central fiber. We present the structures of T5 tail tip, determined by cryo-electron microscopy before and after interaction with its E. coli receptor, FhuA, reconstituted into nanodisc. These structures bring out the important conformational changes undergone by T5 tail tip upon infection, which include bending of T5 central fiber on the side of the tail tip, tail anchoring to the membrane, tail tube opening, and formation of a transmembrane channel. The data allow to detail the first steps of an otherwise undescribed infection mechanism. | ||
| + | |||
| + | Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation.,Linares R, Arnaud CA, Effantin G, Darnault C, Epalle NH, Boeri Erba E, Schoehn G, Breyton C Sci Adv. 2023 Mar 24;9(12):eade9674. doi: 10.1126/sciadv.ade9674. Epub 2023 Mar , 24. PMID:36961893<ref>PMID:36961893</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7qg9" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Escherichia | + | [[Category: Escherichia phage T5]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arnaud CA]] | [[Category: Arnaud CA]] | ||
Current revision
Tail tip of siphophage T5 : common core proteins
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