7qws

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Current revision (12:38, 17 July 2024) (edit) (undo)
 
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==Structure of ribosome translating beta-tubulin in complex with TTC5 and NAC==
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<StructureSection load='7qws' size='340' side='right'caption='[[7qws]]' scene=''>
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<StructureSection load='7qws' size='340' side='right'caption='[[7qws]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7qws]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QWS FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qws OCA], [https://pdbe.org/7qws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qws RCSB], [https://www.ebi.ac.uk/pdbsum/7qws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qws ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qws OCA], [https://pdbe.org/7qws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qws RCSB], [https://www.ebi.ac.uk/pdbsum/7qws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qws ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nascent polypeptide-associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) to prevent mistargeting of cytosolic and mitochondrial polypeptides to the endoplasmic reticulum (ER). How NAC antagonizes SRP and how this is overcome by ER targeting signals are unknown. Here, we found that NAC uses two domains with opposing effects to control SRP access. The core globular domain prevented SRP from binding to signal-less ribosomes, whereas a flexibly attached domain transiently captured SRP to permit scanning of nascent chains. The emergence of an ER-targeting signal destabilized NAC's globular domain and facilitated SRP access to the nascent chain. These findings elucidate how NAC hands over the signal sequence to SRP and imparts specificity of protein localization.
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Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.,Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E Science. 2022 Feb 25;375(6583):839-844. doi: 10.1126/science.abl6459. Epub 2022 , Feb 24. PMID:35201867<ref>PMID:35201867</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7qws" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Ban N]]
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[[Category: Chandrasekaran V]]
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[[Category: Deuerling E]]
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[[Category: Gamerdinger M]]
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[[Category: Hegde R]]
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[[Category: Hsieh H]]
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[[Category: Jomaa A]]
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[[Category: Scaiola A]]
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[[Category: Shan S]]
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[[Category: Ulusoy Z]]
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[[Category: Wallisch A]]

Current revision

Structure of ribosome translating beta-tubulin in complex with TTC5 and NAC

PDB ID 7qws

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