7ywx

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Current revision (12:40, 17 July 2024) (edit) (undo)
 
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==Structure of the human CCAN CENP-A alpha-satellite complex==
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<StructureSection load='7ywx' size='340' side='right'caption='[[7ywx]]' scene=''>
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<StructureSection load='7ywx' size='340' side='right'caption='[[7ywx]], [[Resolution|resolution]] 12.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ywx]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YWX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ywx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ywx OCA], [https://pdbe.org/7ywx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ywx RCSB], [https://www.ebi.ac.uk/pdbsum/7ywx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ywx ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ywx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ywx OCA], [https://pdbe.org/7ywx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ywx RCSB], [https://www.ebi.ac.uk/pdbsum/7ywx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ywx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPL_HUMAN CENPL_HUMAN] Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.<ref>PMID:16716197</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A) nucleosomes (CENP-A(Nuc)) to mediate attachments between chromosomes and the mitotic spindle. We describe cryo-electron microscopy structures of the human inner kinetochore constitutive centromere associated network (CCAN) complex bound to CENP-A(Nuc) reconstituted onto alpha-satellite DNA. CCAN forms edge-on contacts with CENP-A(Nuc), and a linker DNA segment of the alpha-satellite repeat emerges from the fully wrapped end of the nucleosome to thread through the central CENP-LN channel that tightly grips the DNA. The CENP-TWSX histone-fold module further augments DNA binding and partially wraps the linker DNA in a manner reminiscent of canonical nucleosomes. Our study suggests that the topological entrapment of the linker DNA by CCAN provides a robust mechanism by which kinetochores withstand both pushing and pulling forces exerted by the mitotic spindle.
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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.,Yatskevich S, Muir KW, Bellini D, Zhang Z, Yang J, Tischer T, Predin M, Dendooven T, McLaughlin SH, Barford D Science. 2022 May 20;376(6595):844-852. doi: 10.1126/science.abn3810. Epub 2022 , Apr 14. PMID:35420891<ref>PMID:35420891</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7ywx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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*[[Histone 3D structures|Histone 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Barford D]]
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[[Category: Bellini D]]
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[[Category: Dendooven T]]
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[[Category: McLaughlin SH]]
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[[Category: Muir KW]]
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[[Category: Predin M]]
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[[Category: Tischer T]]
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[[Category: Yang J]]
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[[Category: Yatskevich S]]
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[[Category: Zhang Z]]

Current revision

Structure of the human CCAN CENP-A alpha-satellite complex

PDB ID 7ywx

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