Phospholipase A2 homolog
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | '''Phospholipase A2 homolog''' or ''' | + | '''Phospholipase A2 homolog''' or '''Basic phospholipase A2 homolog''' is a snake venom with phospholipase A2 (PLA2) sequence homology and structure homology which has almost no PLA2 activity, i.e., cleaving of fatty acids. The loss of PLA2 catalytic activity is due to the substitution of the conserved Asp49 in the active site by Lys49 in the homolog<ref>PMID:19689412</ref>. |
== Disease == | == Disease == | ||
Current revision
| |||||||||||
3D structures of phospholipase A2 homolog
Updated on 21-July-2024
References
- ↑ Lomonte B, Angulo Y, Sasa M, Gutierrez JM. The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett. 2009;16(8):860-76. doi: 10.2174/092986609788923356. PMID:19689412 doi:http://dx.doi.org/10.2174/092986609788923356
- ↑ Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR. Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin. Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2066-78. doi:, 10.1107/S1399004715014443. Epub 2015 Sep 26. PMID:26457430 doi:http://dx.doi.org/10.1107/S1399004715014443
