8xzn

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Current revision (06:36, 24 July 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xzn is ON HOLD until Paper Publication
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==Crystal structure of folE riboswitch with BH4==
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<StructureSection load='8xzn' size='340' side='right'caption='[[8xzn]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified_eubacterium_clone_A70 Unidentified eubacterium clone A70]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XZN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xzn OCA], [https://pdbe.org/8xzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xzn RCSB], [https://www.ebi.ac.uk/pdbsum/8xzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xzn ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Riboswitches are conserved regulatory RNA elements participating in various metabolic pathways. Recently, a novel RNA motif known as the folE RNA motif was discovered upstream of folE genes. It specifically senses tetrahydrofolate (THF) and is therefore termed THF-II riboswitch. To unravel the ligand recognition mechanism of this newly discovered riboswitch and decipher the underlying principles governing its tertiary folding, we determined both the free-form and bound-form THF-II riboswitch in the wild-type sequences. Combining structural information and isothermal titration calorimetry (ITC) binding assays on structure-based mutants, we successfully elucidated the significant long-range interactions governing the function of THF-II riboswitch and identified additional compounds, including alternative natural metabolites and potential lead compounds for drug discovery, that interact with THF-II riboswitch. Our structural research on the ligand recognition mechanism of the THF-II riboswitch not only paves the way for identification of compounds targeting riboswitches, but also facilitates the exploration of THF analogs in diverse biological contexts or for therapeutic applications.
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Authors:
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Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.,Li C, Xu X, Geng Z, Zheng L, Song Q, Shen X, Wu J, Zhao J, Li H, He M, Tai X, Zhang L, Ma J, Dong Y, Ren A Nucleic Acids Res. 2024 May 20:gkae377. doi: 10.1093/nar/gkae377. PMID:38769061<ref>PMID:38769061</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 8xzn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Unidentified eubacterium clone A70]]
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[[Category: Li CY]]
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[[Category: Ren AM]]

Current revision

Crystal structure of folE riboswitch with BH4

PDB ID 8xzn

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