8acb
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8acb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas] and [https://en.wikipedia.org/wiki/Sweet_potato_feathery_mottle_virus Sweet potato feathery mottle virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ACB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ACB FirstGlance]. <br> | <table><tr><td colspan='2'>[[8acb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas] and [https://en.wikipedia.org/wiki/Sweet_potato_feathery_mottle_virus Sweet potato feathery mottle virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ACB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ACB FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8acb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8acb OCA], [https://pdbe.org/8acb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8acb RCSB], [https://www.ebi.ac.uk/pdbsum/8acb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8acb ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8acb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8acb OCA], [https://pdbe.org/8acb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8acb RCSB], [https://www.ebi.ac.uk/pdbsum/8acb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8acb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/A0A0Y0I2B8_9POTV A0A0Y0I2B8_9POTV] An RNA-dependent RNA polymerase that plays an essential role in the virus replication.[ARBA:ARBA00029404] Has RNA-binding and proteolytic activities.[ARBA:ARBA00029399] Has helicase activity. It may be involved in replication.[ARBA:ARBA00029422] Indispensable for virus replication.[ARBA:ARBA00034080] Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.[ARBA:ARBA00029405] Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs (By similarity). Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation (By similarity). VPg-RNA directly binds EIF4E and is a template for transcription (By similarity). Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation.[ARBA:ARBA00037225] Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.[ARBA:ARBA00029420] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
CryoEM structure of sweet potato feathery mottle virus VLP
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