8ovw

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<StructureSection load='8ovw' size='340' side='right'caption='[[8ovw]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='8ovw' size='340' side='right'caption='[[8ovw]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[8ovw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OVW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[8ovw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OVW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ovw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ovw OCA], [https://pdbe.org/8ovw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ovw RCSB], [https://www.ebi.ac.uk/pdbsum/8ovw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ovw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ovw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ovw OCA], [https://pdbe.org/8ovw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ovw RCSB], [https://www.ebi.ac.uk/pdbsum/8ovw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ovw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/CBF1_YEAST CBF1_YEAST] Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters. DNA-binding activity is enhanced by MET28. Required as an auxiliary factor for transcriptional activation of sulfur metabolism together with MET4 and MET28.<ref>PMID:1549123</ref> <ref>PMID:8665859</ref>
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[https://www.uniprot.org/uniprot/CENPH_YEAST CENPH_YEAST] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.<ref>PMID:9862478</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Cryo-EM structure of CBF1-CCAN bound topologically to centromeric DNA

PDB ID 8ovw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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