1sys

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[[Image:1sys.gif|left|200px]]
[[Image:1sys.gif|left|200px]]
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{{Structure
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|PDB= 1sys |SIZE=350|CAPTION= <scene name='initialview01'>1sys</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1sys", creates the "Structure Box" on the page.
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|SITE=
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|GENE= HLA-B, HLAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1sys| PDB=1sys | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sys OCA], [http://www.ebi.ac.uk/pdbsum/1sys PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sys RCSB]</span>
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'''Crystal structure of HLA, B*4403, and peptide EEPTVIKKY'''
'''Crystal structure of HLA, B*4403, and peptide EEPTVIKKY'''
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[[Category: Tait, B D.]]
[[Category: Tait, B D.]]
[[Category: Zernich, D.]]
[[Category: Zernich, D.]]
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[[Category: b44]]
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[[Category: B44]]
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[[Category: class i]]
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[[Category: Class i]]
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[[Category: hla]]
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[[Category: Hla]]
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[[Category: mhc]]
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[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:17:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:48:47 2008''
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Revision as of 06:17, 3 May 2008

Image:1sys.gif

Template:STRUCTURE 1sys

Crystal structure of HLA, B*4403, and peptide EEPTVIKKY


Contents

Overview

HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into the transporter associated with Ag presentation (TAP)-associated peptide loading complex even under conditions of extreme peptide starvation. This mode of peptide capture is less susceptible to viral interference than the conventional loading pathway used by HLA-B*4402 that involves assembly of class I molecules within the peptide loading complex. Thus, B*4402 and B*4405 are at opposite extremes of a natural spectrum in HLA class I dependence on the PLC for Ag presentation. These findings unveil a new layer of MHC polymorphism that affects the generic pathway of Ag loading, revealing an unsuspected evolutionary trade-off in selection for optimal HLA class I loading versus effective pathogen evasion.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1SYS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion., Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J, J Exp Med. 2004 Jul 5;200(1):13-24. Epub 2004 Jun 28. PMID:15226359 Page seeded by OCA on Sat May 3 09:17:27 2008

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OCA

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