Ras-related protein Rab

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*'''Rab-1A''' is required in stress-induced autophagy<ref>PMID:36781179</ref>.
*'''Rab-1A''' is required in stress-induced autophagy<ref>PMID:36781179</ref>.
*'''Rab-1B''' is required for secretion.
*'''Rab-1B''' is required for secretion.
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*'''Rab-2B''' iregulates Golgi morphology<ref>PMID:26209634</ref>.
+
*'''Rab-2B''' regulates Golgi morphology<ref>PMID:26209634</ref>.
*'''Rab-3A''' is abundant in the brain and plays a role in recruitment of synaptic vesicles for exocytosis<ref>PMID:7911226</ref>.
*'''Rab-3A''' is abundant in the brain and plays a role in recruitment of synaptic vesicles for exocytosis<ref>PMID:7911226</ref>.
*'''Rab-3B''' is essential for the transportation and secretion within cells and its expression is linked to progression of various malignancies<ref>PMID:38688977</ref>.
*'''Rab-3B''' is essential for the transportation and secretion within cells and its expression is linked to progression of various malignancies<ref>PMID:38688977</ref>.
 +
*'''Rab-3C''' promotes vesicle formation and packaging<ref>PMID:26209634</ref>.
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== Disease ==
== Disease ==

Revision as of 10:29, 4 August 2024

Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code 1oix)

Drag the structure with the mouse to rotate

References

  1. ↑ Gyurkovska V, Murtazina R, Zhao SF, Shikano S, Okamoto Y, Segev N. Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence. Life Sci Alliance. 2023 Feb 13;6(5):e202201810. PMID:36781179 doi:10.26508/lsa.202201810
  2. ↑ Aizawa M, Fukuda M. Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. J Biol Chem. 2015 Sep 4;290(36):22250-61. PMID:26209634 doi:10.1074/jbc.M115.669242
  3. ↑ Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, Hammer RE, Südhof TC. The role of Rab3A in neurotransmitter release. Nature. 1994 Jun 9;369(6480):493-7. PMID:7911226 doi:10.1038/369493a0
  4. ↑ Liu XS, Chen YL, Chen YX, Wu RM, Tan F, Wang YL, Liu ZY, Gao Y, Pei ZJ. Pan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers. Sci Rep. 2024 Apr 30;14(1):9881. PMID:38688977 doi:10.1038/s41598-024-60581-x
  5. ↑ Aizawa M, Fukuda M. Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. J Biol Chem. 2015 Sep 4;290(36):22250-61. PMID:26209634 doi:10.1074/jbc.M115.669242
  6. ↑ Bhuin T, Roy JK. Rab11 in disease progression. Int J Mol Cell Med. 2015 Winter;4(1):1-8. PMID:25815277
  7. ↑ Pasqualato S, Senic-Matuglia F, Renault L, Goud B, Salamero J, Cherfils J. The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes. J Biol Chem. 2004 Mar 19;279(12):11480-8. Epub 2003 Dec 29. PMID:14699104 doi:10.1074/jbc.M310558200

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