Rho guanine nucleotide exchange factor

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*'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br />
*'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br />
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*'''Rho guanine nucleotide exchange factor 3''' acts on RHOA and RHOB involved in bone biology.<br />
*'''Rho guanine nucleotide exchange factor 6''' acts on RAC1.<br />
*'''Rho guanine nucleotide exchange factor 6''' acts on RAC1.<br />

Revision as of 09:35, 6 August 2024

Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code 3kz1)

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References

  1. Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. PMID:23303910 doi:http://dx.doi.org/10.1152/physrev.00003.2012
  2. Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep, 16. PMID:24037532 doi:http://dx.doi.org/10.1038/onc.2013.362

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Michal Harel, Joel L. Sussman

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