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1wq6

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(New page: 200px<br /> <applet load="1wq6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wq6, resolution 2.00&Aring;" /> '''The tetramer struct...)
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Revision as of 17:46, 12 November 2007

Image:1wq6.gif

1wq6, resolution 2.00Å

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The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity

Overview

AML1/ETO is the chimeric protein resulting from the t(8;21) in acute, myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates, oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved, the NHR2 domain structure and found it to be an alpha-helical tetramer. We, show that oligomerization contributes to AML1/ETO's inhibition of, granulocyte differentiation, is essential for its ability to enhance the, clonogenic potential of primary mouse bone marrow cells, and affects, AML1/ETO's activity on several endogenous genes. Oligomerization is also, required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not, with other corepressor molecules.

About this Structure

1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331

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