8x80
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of leptin-LepR trimer with a small gap== | |
| - | + | <StructureSection load='8x80' size='340' side='right'caption='[[8x80]], [[Resolution|resolution]] 3.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8x80]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X80 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.88Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: Gao | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x80 OCA], [https://pdbe.org/8x80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x80 RCSB], [https://www.ebi.ac.uk/pdbsum/8x80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x80 ProSAT]</span></td></tr> |
| - | [[Category: Xie | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/LEPR_HUMAN LEPR_HUMAN] Obesity due to leptin receptor gene deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LEPR_HUMAN LEPR_HUMAN] Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gao GF]] | ||
| + | [[Category: Xie YF]] | ||
Current revision
Structure of leptin-LepR trimer with a small gap
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