8x85

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Current revision (05:43, 7 August 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8x85 is ON HOLD until Paper Publication
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==Structure of leptin-LepR dimer==
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<StructureSection load='8x85' size='340' side='right'caption='[[8x85]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
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Authors: Xie, Y.F., Shang, G.J., Qi, J.X., Gao, G.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8x85]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X85 FirstGlance]. <br>
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Description: Structure of leptin-LepR dimer
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.58&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Shang, G.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x85 OCA], [https://pdbe.org/8x85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x85 RCSB], [https://www.ebi.ac.uk/pdbsum/8x85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x85 ProSAT]</span></td></tr>
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[[Category: Gao, G.F]]
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</table>
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[[Category: Xie, Y.F]]
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== Disease ==
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[[Category: Qi, J.X]]
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[https://www.uniprot.org/uniprot/LEPR_HUMAN LEPR_HUMAN] Obesity due to leptin receptor gene deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/LEPR_HUMAN LEPR_HUMAN] Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao GF]]
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[[Category: Qi JX]]
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[[Category: Shang GJ]]
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[[Category: Xie YF]]

Current revision

Structure of leptin-LepR dimer

PDB ID 8x85

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OCA

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