9g2r

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m (Protected "9g2r" [edit=sysop:move=sysop])
Current revision (05:46, 7 August 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9g2r is ON HOLD
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==Endophilin B1 dimers bound to nanodiscs==
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<StructureSection load='9g2r' size='340' side='right'caption='[[9g2r]], [[Resolution|resolution]] 3.88&Aring;' scene=''>
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Authors: Thorlacius, A., Sundborger-Lunna, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9g2r]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G2R FirstGlance]. <br>
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Description: Endophilin B1 dimers bound to nanodiscs
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.88&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g2r OCA], [https://pdbe.org/9g2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g2r RCSB], [https://www.ebi.ac.uk/pdbsum/9g2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g2r ProSAT]</span></td></tr>
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[[Category: Sundborger-Lunna, A]]
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</table>
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[[Category: Thorlacius, A]]
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== Function ==
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[https://www.uniprot.org/uniprot/SHLB1_HUMAN SHLB1_HUMAN] May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).[UniProtKB:Q9JK48]<ref>PMID:11604418</ref> <ref>PMID:15452144</ref> <ref>PMID:17891140</ref> <ref>PMID:20643123</ref> <ref>PMID:21068542</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Sundborger-Lunna A]]
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[[Category: Thorlacius A]]

Current revision

Endophilin B1 dimers bound to nanodiscs

PDB ID 9g2r

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