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1t1d

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[[Image:1t1d.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1d OCA], [http://www.ebi.ac.uk/pdbsum/1t1d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t1d RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF THE SHAKER POTASSIUM CHANNEL'''
'''CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF THE SHAKER POTASSIUM CHANNEL'''
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[[Category: Pfaffinger, P J.]]
[[Category: Pfaffinger, P J.]]
[[Category: Stevens, C F.]]
[[Category: Stevens, C F.]]
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[[Category: aplysia kv1 1]]
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[[Category: Aplysia kv1 1]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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[[Category: proton transport]]
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[[Category: Proton transport]]
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[[Category: tetramerization domain]]
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[[Category: Tetramerization domain]]
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[[Category: x-ray structure]]
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[[Category: X-ray structure]]
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Revision as of 06:23, 3 May 2008

Image:1t1d.gif

Template:STRUCTURE 1t1d

CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF THE SHAKER POTASSIUM CHANNEL


Overview

The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Crystal structures of T1 tetramers from Shaw and Shaker subfamilies reveal a common four-layered scaffolding. Within layer 4, on the hypothetical membrane-facing side of the tetramer, the Shaw T1 tetramer contains four zinc ions; each is coordinated by a histidine and two cysteines from one monomer and by one cysteine from an adjacent monomer. The amino acids involved in coordinating the Zn2+ ion occur in a HX5CX20CC sequence motif that is highly conserved among all Shab, Shaw and Shal subfamily members, but is not found in Shaker subfamily members. We demonstrate by coimmunoprecipitation that a few characteristic residues in the subunit interface are crucial for subfamily-specific tetramerization of the T1 domains.

About this Structure

1T1D is a Single protein structure of sequence from Aplysia californica. Full crystallographic information is available from OCA.

Reference

Zn2+-binding and molecular determinants of tetramerization in voltage-gated K+ channels., Bixby KA, Nanao MH, Shen NV, Kreusch A, Bellamy H, Pfaffinger PJ, Choe S, Nat Struct Biol. 1999 Jan;6(1):38-43. PMID:9886290 Page seeded by OCA on Sat May 3 09:23:03 2008

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