1t1u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1t1u.gif|left|200px]]
[[Image:1t1u.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1t1u |SIZE=350|CAPTION= <scene name='initialview01'>1t1u</scene>, resolution 1.55&Aring;
+
The line below this paragraph, containing "STRUCTURE_1t1u", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Chat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1t1u| PDB=1t1u | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1u OCA], [http://www.ebi.ac.uk/pdbsum/1t1u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t1u RCSB]</span>
+
-
}}
+
'''Structural Insights and Functional Implications of Choline Acetyltransferase'''
'''Structural Insights and Functional Implications of Choline Acetyltransferase'''
Line 34: Line 31:
[[Category: Pedersen, B.]]
[[Category: Pedersen, B.]]
[[Category: Wu, D.]]
[[Category: Wu, D.]]
-
[[Category: choline acetyltransferase]]
+
[[Category: Choline acetyltransferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:24:13 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:02 2008''
+

Revision as of 06:24, 3 May 2008

Image:1t1u.gif

Template:STRUCTURE 1t1u

Structural Insights and Functional Implications of Choline Acetyltransferase


Overview

The biosynthetic enzyme for the neurotransmitter acetylcholine, choline acetyltransferase (ChAT) (E.C. 2.3.1.6), is essential for the development and neuronal activities of cholinergic systems involved in many fundamental brain functions. ChAT catalyzes the transfer of an acetyl group from acetyl-coenzyme A to choline to form the neurotransmitter acetylcholine. Since its discovery more than 60 years ago much research has been devoted to the kinetic studies of this enzyme. For the first time we report the crystal structure of rat ChAT (rChAT) to 1.55 A resolution. The structure of rChAT is a monomer and consists of two domains with an interfacial active site tunnel. This structure, with the modeled substrate binding, provides critical insights into the molecular basis for the production of acetylcholine and may further our understanding of disease causing mutations.

About this Structure

1T1U is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural insights and functional implications of choline acetyltransferase., Govindasamy L, Pedersen B, Lian W, Kukar T, Gu Y, Jin S, Agbandje-McKenna M, Wu D, McKenna R, J Struct Biol. 2004 Nov;148(2):226-35. PMID:15477102 Page seeded by OCA on Sat May 3 09:24:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t1u"
Personal tools