1t27
From Proteopedia
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[[Image:1t27.jpg|left|200px]] | [[Image:1t27.jpg|left|200px]] | ||
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| - | + | {{STRUCTURE_1t27| PDB=1t27 | SCENE= }} | |
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'''THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE''' | '''THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1T27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry | + | 1T27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1fvz 1fvz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T27 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Yarbrough, L R.]] | [[Category: Yarbrough, L R.]] | ||
[[Category: Yoder, M D.]] | [[Category: Yoder, M D.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:25:13 2008'' | |
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Revision as of 06:25, 3 May 2008
THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE
Overview
Eukaryotic phosphatidylinositol transfer protein is a ubiquitous multifunctional protein that transports phospholipids between membrane surfaces and participates in cellular phospholipid metabolism during signal transduction and vesicular trafficking. The three-dimensional structure of the alpha-isoform of rat phosphatidylinositol transfer protein complexed with one molecule of phosphatidylcholine, one of its physiological ligands, has been determined to 2.2 A resolution by x-ray diffraction techniques. A single beta-sheet and several long alpha-helices define an enclosed internal cavity in which a single molecule of the phospholipid is accommodated with its polar head group in the center of the protein and fatty acyl chains projected toward the surface. Other structural features suggest mechanisms by which cytosolic phosphatidylinositol transfer protein interacts with membranes for lipid exchange and associates with a variety of lipid and protein kinases.
About this Structure
1T27 is a Single protein structure of sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 1fvz. Full crystallographic information is available from OCA.
Reference
Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:11104777 Page seeded by OCA on Sat May 3 09:25:13 2008
