8kct

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Current revision (08:15, 14 August 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8kct is ON HOLD until Paper Publication
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==Cryo-EM structure of human gamma-secretase in complex with Nirogacestat==
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<StructureSection load='8kct' size='340' side='right'caption='[[8kct]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Guo, X., Li, H., Kai, U., Yan, C., Lei, J., Zhou, R., Shi, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8kct]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KCT FirstGlance]. <br>
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Description: Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kct OCA], [https://pdbe.org/8kct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kct RCSB], [https://www.ebi.ac.uk/pdbsum/8kct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kct ProSAT]</span></td></tr>
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[[Category: Zhou, R]]
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</table>
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[[Category: Kai, U]]
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== Disease ==
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[[Category: Shi, Y]]
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[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Guo, X]]
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== Function ==
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[[Category: Li, H]]
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[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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[[Category: Lei, J]]
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__TOC__
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[[Category: Yan, C]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Guo X]]
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[[Category: Kai U]]
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[[Category: Lei J]]
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[[Category: Li H]]
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[[Category: Shi Y]]
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[[Category: Yan C]]
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[[Category: Zhou R]]

Current revision

Cryo-EM structure of human gamma-secretase in complex with Nirogacestat

PDB ID 8kct

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OCA

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