8pj5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:16, 14 August 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8pj5 is ON HOLD until Paper Publication
+
==Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5)==
-
 
+
<StructureSection load='8pj5' size='340' side='right'caption='[[8pj5]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8pj5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PJ5 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pj5 OCA], [https://pdbe.org/8pj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pj5 RCSB], [https://www.ebi.ac.uk/pdbsum/8pj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pj5 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IF2P_HUMAN IF2P_HUMAN] Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855).<ref>PMID:10659855</ref> <ref>PMID:12569173</ref> <ref>PMID:35732735</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Fischer N]]
 +
[[Category: Liedtke D]]
 +
[[Category: Peng BZ]]
 +
[[Category: Petrychenko V]]
 +
[[Category: Rodnina MV]]
 +
[[Category: Yi S-H]]

Current revision

Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5)

PDB ID 8pj5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8pj5"
Personal tools