1t2r
From Proteopedia
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[[Image:1t2r.gif|left|200px]] | [[Image:1t2r.gif|left|200px]] | ||
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'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain''' | '''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain''' | ||
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[[Category: Sattler, M.]] | [[Category: Sattler, M.]] | ||
[[Category: Simon, B.]] | [[Category: Simon, B.]] | ||
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Revision as of 06:26, 3 May 2008
Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain
Overview
We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
About this Structure
1T2R is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196 Page seeded by OCA on Sat May 3 09:26:38 2008