1t2r

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[[Image:1t2r.gif|left|200px]]
[[Image:1t2r.gif|left|200px]]
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{{Structure
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|PDB= 1t2r |SIZE=350|CAPTION= <scene name='initialview01'>1t2r</scene>
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The line below this paragraph, containing "STRUCTURE_1t2r", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1t2r| PDB=1t2r | SCENE= }}
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|RELATEDENTRY=[[1t2s|1T2S]], [[1upo|1UPO]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2r OCA], [http://www.ebi.ac.uk/pdbsum/1t2r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t2r RCSB]</span>
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'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
'''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain'''
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[[Category: Sattler, M.]]
[[Category: Sattler, M.]]
[[Category: Simon, B.]]
[[Category: Simon, B.]]
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[[Category: nucleic acid binding protein]]
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[[Category: Nucleic acid binding protein]]
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[[Category: rna]]
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:26:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:25 2008''
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Revision as of 06:26, 3 May 2008

Template:STRUCTURE 1t2r

Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain


Overview

We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.

About this Structure

1T2R is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196 Page seeded by OCA on Sat May 3 09:26:38 2008

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