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Structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue and phosphate (PDB entry 1fv2)

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Clostidium tetani

The Gram positive bacilli Clostridium tetani is the bacteria responsible for the disease state of tetanus. The presence of the bacteria does not cause the disease but instead the toxins it produces cause the disease state. C. tetani produces two toxins; tetanospasmin and tetanolysin or tentoxylysin. Tetanolysin is a cytolysin that increases the permeability of cellular membranes through cell lysis.^[3] Tetanospasmin is the cause of tetanus and is sometimes referred to as tetanus neurotoxin (TeNT), as it acts on the central nervous system. Tetanospasmin makes its way to the central nervous system via retrograde axonal flow beginning with α- motor neurons found in muscle and ending by binding to

Function

Disease

Relevance

Structural highlights

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