TNF receptor-associated factor

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== Function ==
== Function ==
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'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs. '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK. '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>. '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
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'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.
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*'''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.
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*'''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.
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*'''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.
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*'''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
== Structural highlights ==
== Structural highlights ==

Current revision

Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v)

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References

  1. ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
  2. ↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:http://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
  3. ↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:http://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
  4. ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

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