Tyrosine phosphatase
From Proteopedia
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<StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | <StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | ||
| - | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. '''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. Human '''PTP PRL''' is found in regenerating liver. '''PTP class II''' are low molecular weight PTP which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>. '''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. '''Non-receptor type PTPs''' are coded by the PTPN genes. <br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. | + | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. |
| + | *'''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. Human '''PTP PRL''' is found in regenerating liver. | ||
| + | *'''PTP class II''' are low molecular weight PTP which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>. | ||
| + | *'''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. | ||
| + | *'''Non-receptor type PTPs''' are coded by the PTPN genes. <br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br /> | ||
| + | For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. | ||
== Disease == | == Disease == | ||
Revision as of 10:23, 21 August 2024
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References
- ↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
- ↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
- ↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837
