1t3b

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[[Image:1t3b.gif|left|200px]]
[[Image:1t3b.gif|left|200px]]
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{{Structure
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|PDB= 1t3b |SIZE=350|CAPTION= <scene name='initialview01'>1t3b</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1t3b", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DSBC, XPRA, HI1213 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
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|DOMAIN=
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{{STRUCTURE_1t3b| PDB=1t3b | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3b OCA], [http://www.ebi.ac.uk/pdbsum/1t3b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t3b RCSB]</span>
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'''X-ray Structure of DsbC from Haemophilus influenzae'''
'''X-ray Structure of DsbC from Haemophilus influenzae'''
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[[Category: Segatori, L.]]
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[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: protein disulfide isomerase]]
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[[Category: Protein disulfide isomerase]]
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[[Category: protein folding]]
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[[Category: Protein folding]]
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[[Category: redox protein]]
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[[Category: Redox protein]]
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[[Category: redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:27:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:39 2008''
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Revision as of 06:27, 3 May 2008

Image:1t3b.gif

Template:STRUCTURE 1t3b

X-ray Structure of DsbC from Haemophilus influenzae


Overview

Bacterial DsbC proteins are involved in rearranging or reducing mismatched disulfide bonds folding within the periplasm. The X-ray structure of the enzyme from Haemophilus influenzae has been solved and compared with the known structure of the Escherichia coli protein. The proteins act as V-shaped dimers with a large cleft to accommodate substrate proteins. The dimers are anchored by a small N-terminal domain, but have a flexible linker region which allows the larger C-terminal domain, with its reactive sulfhydryls, to clamp down on substrates. The overall folds are very similar, but the comparison shows a wider range of hinge motions than previously thought. The crystal packing of the H. influenzae protein allows the movement of the N-terminal domain with respect to the C-terminal domain through motions in the flexible hinge, generating high thermal parameters and unusually high anisotropy in the crystallographic data.

About this Structure

1T3B is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of DsbC from Haemophilus influenzae., Zhang M, Monzingo AF, Segatori L, Georgiou G, Robertus JD, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1512-8. Epub 2004, Aug 26. PMID:15333920 Page seeded by OCA on Sat May 3 09:27:58 2008

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