1t3q

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[[Image:1t3q.gif|left|200px]]
[[Image:1t3q.gif|left|200px]]
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{{Structure
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|PDB= 1t3q |SIZE=350|CAPTION= <scene name='initialview01'>1t3q</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1t3q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MCN:PTERIN+CYTOSINE+DINUCLEOTIDE'>MCN</scene>, <scene name='pdbligand=SMO:DIOXOSULFIDOMOLYBDENUM(VI)+ION'>SMO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Quinoline_2-oxidoreductase Quinoline 2-oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.17 1.3.99.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1t3q| PDB=1t3q | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3q OCA], [http://www.ebi.ac.uk/pdbsum/1t3q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t3q RCSB]</span>
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}}
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'''Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86'''
'''Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86'''
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[[Category: Martins, B M.]]
[[Category: Martins, B M.]]
[[Category: Purvanov, V.]]
[[Category: Purvanov, V.]]
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[[Category: mcd]]
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[[Category: Mcd]]
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[[Category: molybdenum]]
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[[Category: Molybdenum]]
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[[Category: qor]]
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[[Category: Qor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:29:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:49 2008''
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Revision as of 06:29, 3 May 2008

Image:1t3q.gif

Template:STRUCTURE 1t3q

Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86


Overview

The soil bacterium Pseudomonas putida 86 uses quinoline as a sole source of carbon and energy. Quinoline 2-oxidoreductase (Qor) catalyzes the first metabolic step converting quinoline to 2-oxo-1,2-dihydroquinoline. Qor is a member of the molybdenum hydroxylases. The molybdenum ion is coordinated by two ene-dithiolate sulfur atoms, two oxo-ligands, and a catalytically crucial sulfido-ligand, whose position in the active site was controversial. The 1.8 A resolution crystal structure of Qor indicates that the sulfido-ligand occupies the equatorial position at the molybdenum ion. The structural comparison of Qor with the allopurinol-inhibited xanthine dehydrogenase from Rhodobacter capsulatus allows direct insight into the mechanism of substrate recognition and the identification of putative catalytic residues. The active site protein variants QorE743V and QorE743D were analyzed to assess the catalytic role of E743.

About this Structure

1T3Q is a Protein complex structure of sequences from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase., Bonin I, Martins BM, Purvanov V, Fetzner S, Huber R, Dobbek H, Structure. 2004 Aug;12(8):1425-35. PMID:15296736 Page seeded by OCA on Sat May 3 09:29:00 2008

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