9c7u
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human truncated BOS complex in GDN== | |
| - | + | <StructureSection load='9c7u' size='340' side='right'caption='[[9c7u]], [[Resolution|resolution]] 3.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9c7u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C7U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.65Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c7u OCA], [https://pdbe.org/9c7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c7u RCSB], [https://www.ebi.ac.uk/pdbsum/9c7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c7u ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NCLN_HUMAN NCLN_HUMAN] Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).[UniProtKB:Q6NZ07]<ref>PMID:32820719</ref> <ref>PMID:36261522</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Nguyen VN]] | ||
| + | [[Category: Tomaleri GP]] | ||
| + | [[Category: Voorhees RM]] | ||
Current revision
Structure of the human truncated BOS complex in GDN
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