Ubiquitin activating enzyme

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*'''Uba1''' see [[Uba1]].<br />
*'''Uba1''' see [[Uba1]].<br />
*'''Uba3''' is the catalytic subunit of NEDD8 activating enzyme and APPB1 is its regulatory subunit. Similar to ubiquitin and SUMO, NEDD8 binds to proteins after processing of its C-terminal. <br />
*'''Uba3''' is the catalytic subunit of NEDD8 activating enzyme and APPB1 is its regulatory subunit. Similar to ubiquitin and SUMO, NEDD8 binds to proteins after processing of its C-terminal. <br />
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*'''Uba6''' regulates the interferon-gamma production of T-cells by modulating NF-κB activation pathway<ref>PMID:35011668
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*'''Uba6''' regulates the interferon-gamma production of T-cells by modulating NF-κB activation pathway<ref>PMID:35011668</ref>.
For '''ubiquitin-like modifier-activating enzyme Atg7''' see [[Autophagy-related protein]]
For '''ubiquitin-like modifier-activating enzyme Atg7''' see [[Autophagy-related protein]]

Revision as of 07:45, 22 August 2024

Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (cyan) (PDB entry 1y8x)

Drag the structure with the mouse to rotate

References

  1. Nagai Y, Kaneda S, Nomura K, Yasuda H, Seno T, Yamao F. Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2. J Cell Sci. 1995 Jun;108 ( Pt 6):2145-52. PMID:7673335
  2. Lee JY, An EK, Hwang J, Jin JO, Lee PCW. Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation. Cells. 2021 Dec 29;11(1):105. PMID:35011668 doi:10.3390/cells11010105

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Michal Harel, Alexander Berchansky

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