8q8n
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human GPX4-U46C-I129S-L130S== | |
| - | + | <StructureSection load='8q8n' size='340' side='right'caption='[[8q8n]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q8N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q8n OCA], [https://pdbe.org/8q8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q8n RCSB], [https://www.ebi.ac.uk/pdbsum/8q8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q8n ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bostock MJ]] | ||
| + | [[Category: Conrad M]] | ||
| + | [[Category: Mourao A]] | ||
| + | [[Category: Napolitano V]] | ||
| + | [[Category: Popowicz G]] | ||
| + | [[Category: Sattler M]] | ||
Current revision
Crystal structure of human GPX4-U46C-I129S-L130S
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