8t7n
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the R132H mutant of IDH1 bound to compound 1== | |
| - | + | <StructureSection load='8t7n' size='340' side='right'caption='[[8t7n]], [[Resolution|resolution]] 2.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8t7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T7N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t7n OCA], [https://pdbe.org/8t7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t7n RCSB], [https://www.ebi.ac.uk/pdbsum/8t7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t7n ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Abeywickrema | + | == Disease == |
| - | [[Category: Heo | + | [https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] Defects in IDH1 are involved in the development of glioma (GLM) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. |
| - | [[Category: | + | == Function == |
| - | [[Category: Parthasarathy | + | [https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abeywickrema P]] | ||
| + | [[Category: Heo MR]] | ||
| + | [[Category: Lu J]] | ||
| + | [[Category: McCoy M]] | ||
| + | [[Category: Parthasarathy G]] | ||
| + | [[Category: Soisson SM]] | ||
Current revision
Crystal structure of the R132H mutant of IDH1 bound to compound 1
| |||||||||||
