8yoy
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of HKU1A RBD with TMPRSS2== | |
| - | + | <StructureSection load='8yoy' size='340' side='right'caption='[[8yoy]], [[Resolution|resolution]] 3.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8yoy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Accumulibacter_adiacens Candidatus Accumulibacter adiacens] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YOY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.21Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yoy OCA], [https://pdbe.org/8yoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yoy RCSB], [https://www.ebi.ac.uk/pdbsum/8yoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yoy ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SPIKE_CVHN1 SPIKE_CVHN1] S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Presumably interacts with target cell lipid raft after cell attachment (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Candidatus Accumulibacter adiacens]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cui S]] | ||
| + | [[Category: Ding W]] | ||
| + | [[Category: Gao X]] | ||
| + | [[Category: Shang K]] | ||
| + | [[Category: Zhu H]] | ||
| + | [[Category: Zhu K]] | ||
Current revision
Structure of HKU1A RBD with TMPRSS2
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