1t5s

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[[Image:1t5s.gif|left|200px]]
[[Image:1t5s.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1t5s |SIZE=350|CAPTION= <scene name='initialview01'>1t5s</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1t5s", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1t5s| PDB=1t5s | SCENE= }}
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|RELATEDENTRY=[[1t5t|1T5T]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5s OCA], [http://www.ebi.ac.uk/pdbsum/1t5s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t5s RCSB]</span>
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}}
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'''Structure of the (SR)Ca2+-ATPase Ca2-E1-AMPPCP form'''
'''Structure of the (SR)Ca2+-ATPase Ca2-E1-AMPPCP form'''
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[[Category: Nissen, P.]]
[[Category: Nissen, P.]]
[[Category: Sorensen, T L.M.]]
[[Category: Sorensen, T L.M.]]
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[[Category: calcium pump]]
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[[Category: Calcium pump]]
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[[Category: catalytic mechanism]]
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[[Category: Catalytic mechanism]]
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[[Category: domain movement]]
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[[Category: Domain movement]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: nonhydrolyzable atp analog]]
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[[Category: Nonhydrolyzable atp analog]]
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[[Category: nucleotide binding]]
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[[Category: Nucleotide binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:33:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:51:40 2008''
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Revision as of 06:33, 3 May 2008

Image:1t5s.gif

Template:STRUCTURE 1t5s

Structure of the (SR)Ca2+-ATPase Ca2-E1-AMPPCP form


Overview

A tight coupling between adenosine triphosphate (ATP) hydrolysis and vectorial ion transport has to be maintained by ATP-consuming ion pumps. We report two crystal structures of Ca2+-bound sarco(endo)plasmic reticulum Ca2+-adenosine triphosphatase (SERCA) at 2.6 and 2.9 angstrom resolution in complex with (i) a nonhydrolyzable ATP analog [adenosine (beta-gamma methylene)-triphosphate] and (ii) adenosine diphosphate plus aluminum fluoride. SERCA reacts with ATP by an associative mechanism mediated by two Mg2+ ions to form an aspartyl-phosphorylated intermediate state (Ca2-E1 approximately P). The conformational changes that accompany the reaction with ATP pull the transmembrane helices 1 and 2 and close a cytosolic entrance for Ca2+, thereby preventing backflow before Ca2+ is released on the other side of the membrane.

About this Structure

1T5S is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Phosphoryl transfer and calcium ion occlusion in the calcium pump., Sorensen TL, Moller JV, Nissen P, Science. 2004 Jun 11;304(5677):1672-5. PMID:15192230 Page seeded by OCA on Sat May 3 09:33:43 2008

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