8rvq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==20S proteasome from pre1-1== | |
| - | + | <StructureSection load='8rvq' size='340' side='right'caption='[[8rvq]], [[Resolution|resolution]] 2.02Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8rvq]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RVQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.02Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rvq OCA], [https://pdbe.org/8rvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rvq RCSB], [https://www.ebi.ac.uk/pdbsum/8rvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rvq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSB7_YEAST PSB7_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity.<ref>PMID:8381431</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Dohmen RJ]] | ||
| + | [[Category: Hoeckendorff J]] | ||
| + | [[Category: Kayser F]] | ||
| + | [[Category: Mark E]] | ||
| + | [[Category: Ramos PC]] | ||
| + | [[Category: Wendler P]] | ||
Current revision
20S proteasome from pre1-1
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