8w9i
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-5== | |
| - | + | <StructureSection load='8w9i' size='340' side='right'caption='[[8w9i]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8w9i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W9I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w9i OCA], [https://pdbe.org/8w9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w9i RCSB], [https://www.ebi.ac.uk/pdbsum/8w9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w9i ProSAT]</span></td></tr> |
| - | [[Category: Luo | + | </table> |
| - | [[Category: Zhou | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SYP_PSEAE SYP_PSEAE] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Luo Z]] | ||
| + | [[Category: Zhou H]] | ||
Current revision
Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-5
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