8y52

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Current revision (06:10, 11 September 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8y52 is ON HOLD until Paper Publication
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==Cryo-EM structure of the BA1-bound BRS3-Gq complex==
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<StructureSection load='8y52' size='340' side='right'caption='[[8y52]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8y52]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y52 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y52 OCA], [https://pdbe.org/8y52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y52 RCSB], [https://www.ebi.ac.uk/pdbsum/8y52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y52 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bombesin receptor subtype-3 (BRS3) is an important orphan G protein-coupled receptor that regulates energy homeostasis and insulin secretion. As a member of the bombesin receptor (BnR) family, the lack of known endogenous ligands and high-resolution structure has hindered the understanding of BRS3 signaling and function. We present two cryogenic electron microscopy (cryo-EM) structures of BRS3 in complex with the heterotrimeric G(q) protein in its active states: one bound to the pan-BnR agonist BA1 and the other bound to the synthetic BRS3-specific agonist MK-5046. These structures reveal the architecture of the orthosteric ligand pocket underpinning molecular recognition and provide insights into the structural basis for BRS3's selectivity and low affinity for bombesin peptides. Examination of conserved micro-switches suggests a shared activation mechanism among BnRs. Our findings shed light on BRS3's ligand selectivity and signaling mechanisms, paving the way for exploring its therapeutic potential for diabetes, obesity, and related metabolic disorders.
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Authors:
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Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3.,Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W Cell Rep. 2024 Aug 27;43(8):114511. doi: 10.1016/j.celrep.2024.114511. Epub 2024 , Jul 17. PMID:39024101<ref>PMID:39024101</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 8y52" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li C]]
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[[Category: Xu HE]]
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[[Category: Xu Y]]
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[[Category: Yin W]]

Current revision

Cryo-EM structure of the BA1-bound BRS3-Gq complex

PDB ID 8y52

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OCA

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