9ez3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CLK3 bound to RN129== | |
| - | + | <StructureSection load='9ez3' size='340' side='right'caption='[[9ez3]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ez3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EZ3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ez3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ez3 OCA], [https://pdbe.org/9ez3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ez3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ez3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ez3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Knapp | + | == Function == |
| - | [[Category: Kraemer | + | [https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Kraemer A]] | ||
| + | [[Category: Raig N]] | ||
Current revision
Crystal structure of human CLK3 bound to RN129
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