1t7k

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[[Image:1t7k.gif|left|200px]]
[[Image:1t7k.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1t7k |SIZE=350|CAPTION= <scene name='initialview01'>1t7k</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1t7k", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BH0:3-({5-BENZYL-6-HYDROXY-2,4-BIS-(4-HYDROXY-BENZYL)-3-OXO-[1,2,4]-TRIAZEPANE-1-SULFONYL)-BENZONITRILE'>BH0</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1t7k| PDB=1t7k | SCENE= }}
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|RELATEDENTRY=[[1mui|1MUI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7k OCA], [http://www.ebi.ac.uk/pdbsum/1t7k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t7k RCSB]</span>
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}}
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'''Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea'''
'''Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea'''
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[[Category: Stoll, V S.]]
[[Category: Stoll, V S.]]
[[Category: Vasavanonda, S.]]
[[Category: Vasavanonda, S.]]
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[[Category: arylsulfonamide azacyclic urea]]
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[[Category: Arylsulfonamide azacyclic urea]]
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[[Category: hiv protease]]
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[[Category: Hiv protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:38:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:52:23 2008''
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Revision as of 06:38, 3 May 2008

Image:1t7k.gif

Template:STRUCTURE 1t7k

Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea


Overview

A series of novel azacyclic urea HIV protease inhibitors bearing a benzenesulfonamide group at P1' were synthesized utilizing a parallel synthesis method. Structural studies of early analogs bound in the enzyme active site were used to design more potent inhibitors. The effects of substituting the P1' benzenesulfonyl group on antiviral activity and protein binding are described.

About this Structure

1T7K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors., Huang PP, Randolph JT, Klein LL, Vasavanonda S, Dekhtyar T, Stoll VS, Kempf DJ, Bioorg Med Chem Lett. 2004 Aug 2;14(15):4075-8. PMID:15225729 Page seeded by OCA on Sat May 3 09:38:03 2008

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OCA

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