1t7s

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[[Image:1t7s.gif|left|200px]]
[[Image:1t7s.gif|left|200px]]
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{{Structure
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|PDB= 1t7s |SIZE=350|CAPTION= <scene name='initialview01'>1t7s</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1t7s", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= Bag-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00264 BAG], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK07577 PRK07577]</span>
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{{STRUCTURE_1t7s| PDB=1t7s | SCENE= }}
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|RELATEDENTRY=[[1hx1|1HX1]], [[1i6z|1I6Z]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7s OCA], [http://www.ebi.ac.uk/pdbsum/1t7s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t7s RCSB]</span>
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'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''
'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''
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[[Category: Symersky, J.]]
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[[Category: bag-1 cochaperone]]
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[[Category: Bag-1 cochaperone]]
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[[Category: protein structure initiative]]
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[[Category: southeast collaboratory for structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:38:32 2008''
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Revision as of 06:38, 3 May 2008

Image:1t7s.gif

Template:STRUCTURE 1t7s

Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein


Overview

Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.

About this Structure

1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932 Page seeded by OCA on Sat May 3 09:38:32 2008

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