8yw3

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Current revision (04:55, 18 September 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8yw3 is ON HOLD
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==Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex==
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<StructureSection load='8yw3' size='340' side='right'caption='[[8yw3]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
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Authors: Li, W.Z., Zhou, Q.T., Cong, Z.T., Yuan, Q.N., Li, W.X., Zhao, F.H., Xu, H.E., Zhao, L.H., Yang, D.H., Wang, M.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yw3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YW3 FirstGlance]. <br>
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Description: Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ML:2-METHYLLEUCINE'>2ML</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
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[[Category: Yuan, Q.N]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yw3 OCA], [https://pdbe.org/8yw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yw3 RCSB], [https://www.ebi.ac.uk/pdbsum/8yw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yw3 ProSAT]</span></td></tr>
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[[Category: Wang, M.W]]
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</table>
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[[Category: Li, W.X]]
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== Function ==
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[[Category: Xu, H.E]]
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[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
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[[Category: Li, W.Z]]
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== References ==
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[[Category: Yang, D.H]]
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<references/>
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[[Category: Zhou, Q.T]]
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__TOC__
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[[Category: Zhao, F.H]]
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</StructureSection>
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[[Category: Zhao, L.H]]
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[[Category: Homo sapiens]]
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[[Category: Cong, Z.T]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Cong ZT]]
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[[Category: Li WX]]
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[[Category: Li WZ]]
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[[Category: Wang MW]]
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[[Category: Xu HE]]
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[[Category: Yang DH]]
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[[Category: Yuan QN]]
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[[Category: Zhao FH]]
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[[Category: Zhao LH]]
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[[Category: Zhou QT]]

Current revision

Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex

PDB ID 8yw3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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