8z0f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (04:55, 18 September 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8z0f is ON HOLD until Paper Publication
+
==Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD3==
-
 
+
<StructureSection load='8z0f' size='340' side='right'caption='[[8z0f]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8z0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z0F FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z0f OCA], [https://pdbe.org/8z0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z0f RCSB], [https://www.ebi.ac.uk/pdbsum/8z0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z0f ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/ABCD3_HUMAN ABCD3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ABCD3_HUMAN ABCD3_HUMAN] Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712).[UniProtKB:P33897]<ref>PMID:11248239</ref> <ref>PMID:24333844</ref> <ref>PMID:25168382</ref> <ref>PMID:25944712</ref> <ref>PMID:29397936</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Chen YX]]
 +
[[Category: Hou WT]]
 +
[[Category: Li Y]]
 +
[[Category: Zhou CZ]]

Current revision

Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD3

PDB ID 8z0f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8z0f"
Personal tools