1t8y

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[[Image:1t8y.jpg|left|200px]]
[[Image:1t8y.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1t8y |SIZE=350|CAPTION= <scene name='initialview01'>1t8y</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1t8y", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/AMP_nucleosidase AMP nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.4 3.2.2.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AMN, B1982, Z3139, ECS2779 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1t8y| PDB=1t8y | SCENE= }}
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|RELATEDENTRY=[[1t8r|1T8R]], [[1t8s|1T8S]], [[1t8w|1T8W]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8y OCA], [http://www.ebi.ac.uk/pdbsum/1t8y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t8y RCSB]</span>
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}}
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'''Crystal Structure of E.coli AMP Nucleosidase complexed with phosphate'''
'''Crystal Structure of E.coli AMP Nucleosidase complexed with phosphate'''
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[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
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[[Category: alpha-beta fold]]
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[[Category: Alpha-beta fold]]
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[[Category: alpha-beta-alpha sandwich]]
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[[Category: Alpha-beta-alpha sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:41:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:52:59 2008''
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Revision as of 06:41, 3 May 2008

Image:1t8y.jpg

Template:STRUCTURE 1t8y

Crystal Structure of E.coli AMP Nucleosidase complexed with phosphate


Overview

AMP nucleosidase (AMN) catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate. The enzyme is found only in prokaryotes, where it plays a role in purine nucleoside salvage and intracellular AMP level regulation. Enzyme activity is stimulated by ATP and suppressed by phosphate. The structure of unliganded AMN was determined at 2.7 A resolution, and structures of the complexes with either formycin 5'-monophosphate or inorganic phosphate were determined at 2.6 A and 3.0 A resolution, respectively. AMN is a biological homohexamer, and each monomer is composed of two domains: a catalytic domain and a putative regulatory domain. The overall topology of the catalytic domain and some features of the substrate binding site resemble those of the nucleoside phosphorylases, demonstrating that AMN is a new member of the family. The structure of the regulatory domain consists of a long helix and a four-stranded sheet and has a novel topology.

About this Structure

1T8Y is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases., Zhang Y, Cottet SE, Ealick SE, Structure. 2004 Aug;12(8):1383-94. PMID:15296732 Page seeded by OCA on Sat May 3 09:41:13 2008

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