1tb6

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[[Image:1tb6.jpg|left|200px]]
[[Image:1tb6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1tb6 |SIZE=350|CAPTION= <scene name='initialview01'>1tb6</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1tb6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GU0:2,3,6-TRI-O-SULFONATO-ALPHA-L-GALACTOPYRANOSE'>GU0</scene>, <scene name='pdbligand=GU1:2,3-DI-O-METHYL-BETA-D-GLUCOPYRANURONIC+ACID'>GU1</scene>, <scene name='pdbligand=GU2:2,3-DI-O-METHYL-ALPHA-L-IDOPYRANURONIC+ACID'>GU2</scene>, <scene name='pdbligand=GU3:METHYL+3-O-METHYL-2,6-DI-O-SULFONATO-ALPHA-D-GLUCOPYRANOSIDE'>GU3</scene>, <scene name='pdbligand=GU4:2,3,4,6-TETRA-O-SULFONATO-ALPHA-D-GLUCOPYRANOSE'>GU4</scene>, <scene name='pdbligand=GU5:2,3-DI-O-METHYL-6-O-SULFONATO-ALPHA-D-GLUCOPYRANOSE'>GU5</scene>, <scene name='pdbligand=GU6:2,3,6-TRI-O-SULFONATO-ALPHA-D-GLUCOPYRANOSE'>GU6</scene>, <scene name='pdbligand=GU8:2,3,6-TRI-O-METHYL-BETA-D-GLUCOPYRANOSE'>GU8</scene>, <scene name='pdbligand=GU9:2,3,6-TRI-O-METHYL-ALPHA-D-GLUCOPYRANOSE'>GU9</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SERPINC1, AT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1tb6| PDB=1tb6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tb6 OCA], [http://www.ebi.ac.uk/pdbsum/1tb6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tb6 RCSB]</span>
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}}
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'''2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex'''
'''2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex'''
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[[Category: Johnson, D J.]]
[[Category: Johnson, D J.]]
[[Category: Li, W.]]
[[Category: Li, W.]]
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[[Category: heparin]]
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[[Category: Heparin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:45:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:53:47 2008''
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Revision as of 06:45, 3 May 2008

Image:1tb6.jpg

Template:STRUCTURE 1tb6

2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex


Contents

Overview

The maintenance of normal blood flow depends completely on the inhibition of thrombin by antithrombin, a member of the serpin family. Antithrombin circulates at a high concentration, but only becomes capable of efficient thrombin inhibition on interaction with heparin or related glycosaminoglycans. The anticoagulant properties of therapeutic heparin are mediated by its interaction with antithrombin, although the structural basis for this interaction is unclear. Here we present the crystal structure at a resolution of 2.5 A of the ternary complex between antithrombin, thrombin and a heparin mimetic (SR123781). The structure reveals a template mechanism with antithrombin and thrombin bound to the same heparin chain. A notably close contact interface, comprised of extensive active site and exosite interactions, explains, in molecular detail, the basis of the antithrombotic properties of therapeutic heparin.

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1TB6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin., Li W, Johnson DJ, Esmon CT, Huntington JA, Nat Struct Mol Biol. 2004 Sep;11(9):857-62. Epub 2004 Aug 15. PMID:15311269 Page seeded by OCA on Sat May 3 09:45:31 2008

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OCA

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